Recent advance in brown adipose physiology and its therapeutic potential

Brown adipose tissue (BAT) is a specialized thermoregulatory organ that has a critical role in the regulation of energy metabolism. Specifically, energy expenditure can be enhanced by the activation of BAT function and the induction of a BAT-like catabolic phenotype in white adipose tissue (WAT). Since the recent recognition of metabolically active BAT in adult humans, BAT has been extensively studied as one of the most promising targets identified for treating obesity and its related disorders. In this review, we summarize information on the developmental origin of BAT and the progenitors of brown adipocytes in WAT. We explore the transcriptional control of brown adipocyte differentiation during classical BAT development and in WAT browning. We also discuss the neuronal control of BAT activity and summarize the recently identified non-canonical stimulators of BAT that can act independently of beta-adrenergic stimulation. Finally, we review new findings on the beneficial effects of BAT activation and development with respect to improving metabolic profiles. We highlight the therapeutic potential of BAT and its future prospects, including pharmacological intervention and cell-based therapies designed to enhance BAT activity and development.

A Study on Hazard Assessment of Employees in New Buildings

In order to evaluate the physical and psychological health effects of air pollutants from new building materials, 100 employees who worked in new buildings were given a general health questionnaire, and the prevalence of their subjective complaints was measured. The collected data were classified according to age, gender, smoking status, profession, working time, sleep time, life style, and length of employment. The results obtained were summarized as follows: The THI lie scale scores were significantly higher among the older respondents. Compared to males, females showed a significantly higher level in the depression itemas well asa tendency toward high ratios of physical and psychological complaints. The smoking group showed higher scores regarding health complaints related to most physical and psychological items. Smokers showed significantly increased respiratory organ complaints compared to nonsmokers. Those with a profession showed significantly higher level of nervousness. The group of those working 7 to 10 hours group showed higher rates of complaints in the multiple subjective symptoms and mouth/anus items than the group working less than 2 hours. Those living an irregular life showed a tendency toward higher rates of complaints for most physical and psychological subjective factors. Those who were satisfied with their environments showed significantly lower scores in the mouth/anus, impulsiveness, mental irritability, depression, and nervousness items. In summary, this study shows that the health complaint scores regarding physical and psychological symptoms tended to be higher among the unsatisfied group, the irregular life group, the group who worked long hours, the elderly, smokers, and females. These results can be used to improve the psychosomatic health status and working environments of employees working in new buildings.

A Study on Health Hazards to Employees near Main Streets

In order to evaluate the physical and psychological health effects from automobile air pollution, 99 employees who worked near a main street were given a general health questionnaire, and the prevalence of their subjective complaints was measured. The collected data were classified according to gender, sleep time, degree of regular exercise, self-consciousness of symptoms, length of employment, work time, rest time, and smoking status. The results obtained were summarized as follows: The scores related to health complaints regarding physical and psychological items were higher in females than in males. THI scores were higher for the 4 years showed significantly higher rates of complaints regarding the eyes and skin. THI scores were higher for the < 6 hour working time group. The smoking group showed higher scores regarding health complaints related to physical items. The THI scores of the respiratory organs, mouth, anus, and digestive organs were significantly higher for the smoking group than for the non-smoking group. In summary, this study shows that the health complaint scores regarding physical and psychological symptoms tended to be higher among the unhealthy group, the less sleep time group, the less work time group, smokers, and females. These results can be used to improve the psychosomatic health status and working environments of employees who work near a main street.